Psychopharmacologic violence associated with cocaine abuse: kindling of a limbic dyscontrol syndrome?
by
Davis WM
Department of Pharmacology and
Research Institute of Pharmaceutical Sciences
School of Pharmacy,
University of Mississippi, USA.
Prog Neuropsychopharmacol Biol Psychiatry 1996 Nov; 20(8):1273-300
ABSTRACT1. An association of cocaine abuse with aggressive or violent behavior arising from direct pharmacologic effects of cocaine is demonstrable in the forensic and clinical literature. 2. The neurobehavioral basis for this association is considered form among known CNS actions of cocaine. A hypothesis is developed concerning the role of pharmacological kindling by cocaine that may sensitize for release of limbic-hypothalamic mechanisms of aggressive behavior, and for a drug-induced dyscontrol syndrome. 3. Parallels are drawn to kindling by electrical stimuli, and to neurophysiological research on mechanisms of aggression. 4. A role of concurrent hyperthermic effects of cocaine is suggested. 5. Potential contributions of cocaine actions on CNS serotonergic, catecholaminergic and/or adenosinergic systems are considered. 6. A likely role of concurrent ethanol ingestion to enhance the manifestation of cocaine-associated violence is recognized. 7. Pharmacological challenges, lidocaine or caffeine, are suggested as a means of detecting lowered thresholds of limbic excitability as a consequence of repeated cocaine exposures.History
Crack and crime
Prenatal cocaine
Dopaminergic flies?
Dopaminergic agents
Coca leaves/cocaine
Cocaine immunization
The coke-craving brain
Cocaine and the lonely rat
Monoamines, cocaine and rats
Freebasing flies go hyperkinetic
Tasering cocaine-intoxicated pigs01 02 03 04 05 06 07 08 09 10 11 12
13 14 15 16 17 18 19 20 21 22 23 24
Refs
HOME
HedWeb
cannabis-marijuana.com
Future Opioids
BLTC Research
Wirehead Hedonism
Paradise-Engineering
Utopian Pharmacology
The Hedonistic Imperative
When Is It Best to Take Crack Cocaine?
The Good Drug Guide
The Responsible Parent's Guide To
Healthy Mood Boosters For All The Family
