Involvement of 5-HT(3) receptors in the nucleus accumbens in the potentiation of cocaine-induced behaviours in the rat
by
Herges S, Taylor DA
Department of Pharmaceutical Biology and Pharmacology,
Victorian College of Pharmacy,
Monash University,
381 Royal Parade, Parkville 3052,
Victoria, Australia.
Br J Pharmacol 2000 Dec 7;131(7):1294-1302

ABSTRACT

The present study investigated the central effects of the selective serotonin reuptake inhibitor (SSRI) fluoxetine and the role of 5-hydroxytryptamine(3) (5-HT(3)) receptors in the core of the nucleus accumbens (NAc) on cocaine-induced behavioural changes in rats. The 5-HT(3) receptor antagonist ondansetron (1 or 10 ng) was microinjected bilaterally into the core of the NAc 60 min prior to peripheral cocaine (15 mg kg(-1), i.p.) administration followed by the assessment of locomotor activity, rearing activity and head bobs. Both doses of ondansetron attenuated cocaine's stimulatory effect on behaviours. Fluoxetine (0.05 or 5 mug) microinjected bilaterally into the core of the NAc 30 min before peripheral administration of cocaine produced dose-dependent biphasic effects on cocaine-induced behaviours. Intra-NAc administration of 0.05 mug fluoxetine resulted in a potentiation of cocaine-induced behaviours, while the higher dose of the SSRI (5 mug) attenuated the stimulant effect of cocaine on behaviours. To investigate a possible involvement of 5-HT(3) receptors in fluoxetine's facilitatory action, ondansetron (10 ng) was microinjected 30 min prior to fluoxetine (0.05 mug), which resulted in a significant attenuation of the facilitatory effect of fluoxetine on cocaine-induced behaviours. Thus, 5-HT(3) receptors in the core of the NAc appear to mediate stimulatory effects on cocaine-induced locomotor activity, rears and head bobs, whereas the attenuation of cocaine-induced behaviours by fluoxetine at the higher dose, suggests the involvement of a different 5-HT receptor subtype.

5-HT3
5-HT1a
5-HT1b
5-HT2a
5-HT2c
Reward
Anxiety
Metabolism
Oral cocaine
Dopaminergic flies?
Dopaminergic agents
Cocaine and serotonin

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