Sucrose intake enhances behavioral sensitization
produced by cocaine
by
Gosnell BA.
Neuropsychiatric Research Institute,
P.O. Box 1415, Fargo,
ND 58107, USA.
Brain Res. 2005 Jan 21;1031(2):194-201
ABSTRACTMany studies have reported relationships between the intake or preference for sweets and the effects or self-administration of drugs of abuse. This study was conducted to determine whether intermittent access to sucrose would alter the activity response to an injection of cocaine (15 mg/kg, i.p.) or the degree to which repeated cocaine injections produce behavioral sensitization. Nondeprived rats were given 1 h access to granulated sucrose, ground chow, or alternating sucrose and chow for 38 days. Activity levels were measured after injections of saline and cocaine. Rats were also tested after a total of seven cocaine injections, and again 14 days later with no intervening treatments. There was an on overall facilitation of the response to cocaine in rats exposed to sucrose, compared to rats exposed only to ground chow. Subsequent analyses indicated that after the seventh cocaine injection, there was a significant increase in activity of the sucrose group early in the session (compared to the chow group). When tested 14 days later, there was a prolongation of the effect of cocaine in the sucrose group. These results are in partial agreement with the results of others on amphetamine-elicited activity and suggest that some degree of potentiation or cross-sensitization between sucrose and psychostimulants is possible.Dopamine
The pleasure centres
The nucleus accumbens
Dopamine/D1receptors
Dopamine/D2 receptors
Dopamine/D3 receptors
Dopamine/D4 receptors
Sensitisation/D2 receptor function in mPFC01 02 03 04 05 06 07 08 09 10 11 12
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