Progressive septal and palatal perforation
secondary to intranasal cocaine abuse
by
Gendeh BS, Ferguson BJ, Johnson JT, Kapadia S
Department of Otorhinolaryngology-
Head and Neck Surgery,
Faculty of Medicine,
Hospital National University of Malaysia,
Kuala Lumpur.
Med J Malaysia 1998 Dec; 53(4):435-8
ABSTRACTSeptal perforation from intranasal cocaine abuse is well recognised. We present a case of progressive septal as well as palatal perforation. Progression from septal perforation to palatal perforation occurred after cessation of intranasal cocaine abuse. This patient had a weakly positive cytoplasmic antineutrophilic cytoplasmic antibody (C-ANCA) but no histologic evidence of Wegener's Granulomatosis. The differential diagnosis for septal and palatal perforation is reviewed. This case represents the fifth reported case of palatal perforation secondary to cocaine abuse in the literature, and the second associated with positive C-ANCA.Nasal destruction
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