The effect of the dopamine neuronal reuptake inhibitor GBR 12909 on the dopaminergic neurotransmission parameters in the rat striatum in vivo
by
Budygin EA, Kilpatrick M, Gainetdinov RR, Raevskii KS, Wightman RM
Department of Chemistry,
University of North Carolina,
Chapel Hill, USA.
Eksp Klin Farmakol 1999 Sep-Oct; 62(5):3-6
ABSTRACTThe aim of the present research was to investigate the effects of the selective dopamine re-uptake inhibitor GBR 12909 (10 mg/kg, i.p.) on dopaminergic neurotransmission in rat striatum. GBR 12909 increased DA levels in microdialysis samples from freely moving rats. In contrast, administration of GBR 12909 slightly decreased the NSD 1015 (50 mg/kg)--induced DOPA accumulation. This result may be explained as a decrease in DA biosynthesis in response to an increasing amount of DA in the synaptic cleft. Fast-scan cyclic voltammetric monitoring of electrically-evoked DA showed significant changes after the drug in DA re-uptake (Km), but not DA release. In conclusion, our results support the notion, that GBR 12909 is a specific DA uptake inhibitor without any transmitter releasing action.AJ76
GBR12909
Dopamine
Noradrenaline
Cocaine hotspots
Dopaminergic flies?
Dopaminergic agents
"Cocaine antagonists"
The coke-craving brain
Monoamines, cocaine and rats
Freebasing flies go hyperkinetic01 02 03 04 05 06 07 08 09 10 11 12
13 14 15 16 17 18 19 20 21 22 23 24
MORE
HedWeb
HerbWeb
BLTC Research
Wirehead Hedonism
Paradise-Engineering
Utopian Pharmacology
The Hedonistic Imperative
When Is It Best to Take Crack Cocaine?
The Good Drug Guide
The Responsible Parent's Guide To
Healthy Mood Boosters For All The Family
