Functional magnetic resonance imaging of human
brain activation during cue-induced cocaine craving
by
Maas LC; Lukas SE; Kaufman MJ; Weiss RD;
Daniels SL; Rogers VW; Kukes TJ; Renshaw PF
Brain Imaging Center,
McLean Hospital,
Belmont, MA 02178, USA.
lcmaas@mclean.harvard.edu
Am J Psychiatry, 1998 Jan, 155:1, 124-6

ABSTRACT

OBJECTIVE: Functional magnetic resonance imaging (MRI) was used to test whether brain activation was detectable in regions previously associated with cocaine cue-induced craving. METHOD: Blood oxygenation level dependent (BOLD) functional activation was measured during presentation of audiovisual stimuli containing alternating intervals of drug-related and neutral scenes to six male subjects with a history of crack cocaine use and six male comparison subjects. RESULTS: Significant activation was detected in the anterior cingulate and left dorsolateral prefrontal cortex in the cocaine-using group. In addition, a correlation between self-reported levels of craving and activation in these regions was found. CONCLUSIONS: These results suggest that functional MRI may be a useful tool to study the neurobiological basis of cue-induced craving.

AJ 76
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